Jumper (2021)
AlphaFold predicts protein structures with near-experimental accuracy, but sequence alone still sets the boundary
AlphaFold combined evolutionary information with explicit geometric reasoning to outperform every other method at CASP14. Its predictions are fast and unusually accurate, provided the sequence carries enough evidence about the structure.
- 0.96 Å
- median CASP14 backbone error, compared with 2.8 Å for the next-best method
- 1.5 Å
- median all-atom error, compared with 3.5 Å for the strongest alternative